The Charnoly Body: A Novel Biomarker of Mitochondrial

The Charnoly Body: A Novel Biomarker of Mitochondrial Bioenergetics Diversified physicochemical injuries trigger Charnoly body CB formation as pleomorphic, electron dense, multi lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis CB is eliminated by energy ATP driven lysosome dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases Accumulation of CB at the junction of axon hillock and charnolosome CS at the synapses causes cognitive impairments whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug resistant malignancies Hence, stem cell specific CB, charnolophagy, and CS agonists antagonists are introduced as novel charnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer Nanoparticles to improve drug delivery, CS exocytosis, and disease specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants The book will be of interest to medical scientists and practitioners

About the Author: Sushil Sharma

Is a well known author, some of his books are a fascination for readers like in the The Charnoly Body: A Novel Biomarker of Mitochondrial Bioenergetics book, this is one of the most wanted Sushil Sharma author readers around the world.

Leave a Reply

Your email address will not be published. Required fields are marked *

Back To Top